A Survey on prevalent bacterial agents of urinary tract infections and Relationship of this infections with ABO, Rh & P1 blood group antigens

نهمين كنگره بين المللي آزمايشگاه و بالين و دومين كنگره ملي علوم پايه پزشكي و توليد دانش بنيان

3 الي 6 اسفند 1395، تهران - ايران

Presentation Type: Poster
Abstract: Background and Aim : Urinary tract infections (UTIs) are one the most common bacterial infections in human. There are many predisposing factors which are facilitating UTIs such as bacterial virulence factors, anatomical defects in urinary tract system and so on. A predisposition to urinary tract infection (UTI) is associated with the expression of P1 as well as the presence of ABO blood group antigen on the boundary layer and with the secretor state. Infectious microorganisms interfere with specific molecules on epithelial cells, these are antigens of the P1 and ABO blood group system. P1 antigens suggested to being as a receptor for bacterial fimbriae like E. coli. In this study, we investigated the relationship between UTIs and blood group antigens in patients referred to medical diagnostic laboratories of Urmia, Iran. Methods : During MarchSeptember a total of 318 patients with UTIs that referred to these laboratories were subjected to further studies. Bacterial agents of UTls were identified by using selective and differential culture media and standard microbiological tests. ABO, Rh blood group determination were performed by slide agglutination test and P1 antigen was detected using test tube agglutination method as recommended by manufacturer. Collected data were analyzed by the computer software Excel, ver.2013 and SPSS, ver.19 for Windows (SPSS Inc., Chicago, IL, USA) and chi-square χ2 test was run to compare relative frequency of infection between different groups. Differences were considered significant when p​<0.05. 
Results : From 318 studied patients 180 (56.60%) belonged to females and 138 (43.40%) were males. According to the results, The infection rate was independent of sex. The frequency of the bacterial agents in specimen are as fallow: E.coli, Klebsiella, Coagulase negative Staphylococci, Citrobacter, Entrobacter, Pseudomonas, Proteus and Entrococci (p​<0.05). Determination of ABO, Rh blood group by slide agglutination method showed that A+, B+ and 0+ were the most common phenotype among patients also 170 (53.46%) of patients had P1 antigens on their Red blood cells. There was a significant difference between control groups and patients that had these blood groups (p​<0.05) 
Conclusion : Previous studies suggest the increase rate of UTIs in patients with P1 antigen and also, concordance of UTIs with especial blood group antigens as seen in our study, but in order to make a reliable correlation between blood groups and UTls it is recommended to study the distribution of ABO, Rh and P1 antigens on large population.