Background: Premenstrual syndrome can cause problems in daily work and relationships. it is important to resolve the problems of the patients. Due to the chronic nature of the disease, this study aimed to evaluate the effect of non‐ chemical medicine such as Vitamin D and Vitamin E Supplements on the severity of PMS in the patients affected by the disease
Methods: Eighty six women were randomly assigned to two intervention groups and one control group. Patients were asked to fill out the premenstrual syndrome(PMS)PMS Daily Symptoms Record for two months, and then the participants were randomly assigned to one of the three study groups. Medical intervention was carried out for two months with the participants in each group receiving either a tablet containing 200 mg Vitamin D,100 mg Vitamin E, or a placebo each day, respectively. After two months, the results of pre‐ and post‐intervention were compared. The P <0.05was considered significant.
Results: After the intervention, the mean score of the syndrome (37.4,38.9, 35.2 in vitamin Placebo respectively) (significantly decreased in all the three groups(12,16, and 8 decreased scores in vitamin D,E, and placebo, respectively). The differences between groups were not significant
Conclusions: Supplemental therapy with vitamins D and E is an effective and affordable treatment for PMS. With regard to the periodic and chronic nature of the syndrome, administration of the drug seems to be feasible.