Presentation Type: Poster
Abstract: Introduction: Medical plants have been intensively studied as a source of antitumor compounds. The antitumor effects of the Scrophularia oxysepala medicinal plant extract is not studied on the mouse mammary carcinoma. In the present study, we determine the effect of Scrophularia oxysepala on triggering apoptosis in BALB/c mice.
Material & methods: After the emergence of tumor in BALB/c mouse, two groups of mice were received the extract at two doses of 50 and 100 mg kg-1 respectively using intraperitoneal injection for 28 days. In order to assess the induction of apoptosis in cancer cells, the tunnel assay was carried out in mice.
Results: According to the findings, the Scrophularia oxysepala extract inhibits tumor growth. The weight of tumor mass in treated mice after resection was less than the control group. According to the TUNEL assay results, the herbal extract was able to induce apoptosis.
Conclusion: our data well established the anti-proliferative effect of Scrophularia oxysepala extract, and clearly showed that the plant extract can decrease the growth of breast tumors, thus it may represent an ideal therapeutic tool for breast cancer.