The haplotype FAS-1377G-670A as a genetic biomarker to predict a lower risk of breast cancer in East Azarbaijan province
18 الي 20 آبان 1395، تبريز - ايران
Presentation Type: Poster
Abstract: Background: Breast cancer is the most common cancer in women. Fas is the initiator of the apoptotic pathway. Polymorphisms in the FAS gene impair apoptotic signal transduction and may be significant in cancer development.
Purposes: The object of the present study is the association analysis of FAS polymorphisms and haplotypes with the breast cancer risk in East Azerbaijan province.
Methods: The study was done on 157 breast cancer patients and 130 healthy controls. Genotype determination was performed using Tetra-ARMS-PCR for rs2234767 and RFLP-PCR for rs1800682. For statistical analysis, p0.05). The -1377G-670A haplotype has a higher frequency among controls rather than patients, significantly (65% versus 58%) (p=0.045). There was no significant difference for other haplotypes between patients and controls (p>0.05).
Conclusion: The present study indicates that FAS promoter polymorphisms are not predisposing factor for breast cancer in East Azarbaijan province. The -1377G-670A haplotype has a protective effect on breast cancer development in this province. Further studies are needed to determine the role of FAS polymorphisms in breast cancer development.