Presentation Type: Poster
Abstract: Background:Uncoupling proteins (UCPs) are mitochondrial transporters present in the inner membrane of mitochondria and act as proton carriers. They are able to dissipate the proton gradient, reduce the membrane potential and produce Reactive Oxygen Species (ROS). It has been suggested that ROS and cellular oxidant stress have been associated with cancer. The ability of cancer cells to regulate ROS levels contributes greatly to autonomous growth, the evasion of apoptosis, and other hallmark characteristics of adaptation. Thus, UCP2 activity, a negative regulator of ROS, should be related to cancer development or progression. Increased UCP2 expression has been observed in Most of cancers , but not well understood in breast cancer. In this study we evaluate the association between UCP2 expression and Clinicopathological characteristics of breast cancer patients in Iran.
Materials and Methods:In the present study 35 breast cancer patients referred to Cancer Research Center of Imam Khomeini hospital between 2007-2009 years were analysed.Patients did not receive chemotherapy or radiotherapy before surgery. UCP2 gene expression and β-actin gene expression as a reference gene were assessed using quantitative Real-time PCR.
Results: Data were analysed by SPSS software. Over-expression of UCP2 gene was seen in 37% of patients. 20% of patients have shown no difference in expression levels. Also there was no association between UCP2 gene expression and clinical features of the patients.
Conclusion:Result showed UCP2 expression is correlated significantly with breast cancer in Iranian women.