Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by the new derivative from Pyranochromenes family

اولين كنگره بين المللي تازه هاي پيشگيري، تشخيصي و درماني سرطان پستان

18 الي 20 آبان 1395، تبريز - ايران

Presentation Type: Poster
Abstract: Background and aim: Cancer is a disease in which abnormal cells divide without control. This disease is one of the major causes of death in the world. Today there is a wide range of therapies such as chemotherapy, radiotherapy, and target therapy. However, chemotherapy has been associated with harmful side effects and resistance. According to these problems, new compounds are investigated to find out any agents which have fewer side effects and more antitumor activity. Among all agents, Pyrano-chromene family derivatives are a group of heterocyclic compounds, which can be important. In the present study, have been investigated the effects of a new derivative of the pyrano-chromene family on proliferation, viability, and induction of apoptosis in the MCF-7 cell line.
Materials and methods: In this study, the human MCF-7 cell line as an experimental model for breast cancer was treated with various concentrations of the compound. MTT test determined viability and cell growth inhibition. Following by the induction of apoptosis through fluorescence microscopy and electrophoresis in MCF-7 cells was investigated.
Results: Our study showed that: 1) this compound reduced viability in MCF-7 cells to concentration- and time-dependent manner, 2) this compound was also induced apoptosis.
Conclusion: According to the growth inhibitory and apoptotic effects of the new derivative can be proposed as compounds for pharmaceutical evaluation in the future.