Presentation Type: Poster
Abstract: Background: Paget’s disease of the breast is an uncommon type of breast cancer that usually first shows as changes to the nipple. It occurs in less than 5% of all women with breast cancer. Men can also get Paget’s disease but this is very rare.
Symptoms: The most common symptom is a red, scaly rash involving the nipple, which may spread to the areola. The rash can feel itchy or you may have a burning sensation. The nipple may be inverted (pulled in) and there may also be discharge from the nipple.
Histopathology: In early lesions of paget disease of the breast , the epidermis usually shows only a few scattered paget cells. They are large , rounded cells that are devoid of intercellular bridges and contain a large nucleus and ample cytoplasm. The cytoplasm of these cells stains much lighter than that of the adjacent squamous cells. As the number of paget cells increases .they compress the squamous cells to such an extent that the latter may merely form a network, the meshes of which are filled with paget cells lying singly and in groups. The dermis in paget disease shows a moderately severe chronic inflammatory reaction. Although paget cells do not invade the dermis from the epidermis , they may be seen extending from the epidermis into the epithelium of hair follicles. Histologic examination of the mammary ducts and glands nearly always shows malignant changes in some of them . At first the carcinoma is confined within the walls of the ducts and glands , but the tumor cells ultimately invade the connective tissue . From then on, lymphatic spread and metastases occur. In mammary paget disease, the malignant changes have their onset in the lactiferous ducts and from there extend into the epidermis.