Effect of exercise training on functional capacity and N-terminal pro-brain natriuretic peptide level in patients with heart failure undergoing coronary artery angioplasty

پنجمين كنگره بين المللي پيشگيري از بيماريهاي قلب و عروق

7 الي 9 مهر 1395، شيراز - ايران

Presentation Type: Poster

Background: In spite of major advances in pharmacological treatment for patients with heart failure, a number of patients still suffers from dyspnea and reduced functional capacity. N-terminal pro-brain natriuretic peptide (NT-pro BNP) is a predictor of adverse outcomes in this population. The aim of this study was to evaluate the effect of exercise training on functional capacity and plasma level of NT-pro BNP in patient with heart failure undergoing coronary artery angioplasty.
Materials and methods: Twenty patients (left ventricular ejection fraction 32.7%±5.9%; age 57.9±8.0 years; 15/5 male/female) with heart failure that underwent coronary angioplasty were randomly allocated to either a training (n=10) or a control group (n=10).The training group performed endurance training for a total duration of 45 minutes at 40-70% of peak VO2, three times a week for 7 weeks. The control group received usual care. A symptom-limited exercise test was performed at baseline and the end of the 7 weeks for estimating functional capacity in metabolic equivalent value (METs), and at the same times NT-pro BNP level were measured. All statistical analyses were performed in SPSS version 23.
Results: The functional capacity improved from 7.6±2.4 to 9.4±2.6 METs in training group (P=0.007). NT-pro BNP level decreased from 32.1±31.1 to 14.8±15.0 pmol/l (P=0.022).Increase in functional capacity with training correlated significantly with the decrease in NT-pro BNP (p=0.029).patients who did not undergo training showed no significant changes (P>0.05).
Conclusion: Endurance training has favorable effects on functional capacity and neurohormonal modulation in patients with heart failure.