Presentation Type: Speech

Epidemiologic studies have found a graded relationship between the total cholesterol concentration and coronary risk.
Patients with known coronary heart disease or other cardiovascular disease including symptomatic carotid artery disease, peripheral vascular disease, abdominal aortic aneurysm or combinations of risk factors that result in a 10-year risk of CVD events of more than 20 percent clearly benefit from treatment with a statin. Patients without known CVD are generally at much lower baseline risk of cardiovascular (CV) events. As such, the treatment approach will depend on a determination of global CVD risk, as the potential absolute risk reduction with treatment for hypercholesterolemia will usually be smaller than for patients with established CVD.

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