Bone marrow stem cell application for terminal heart failure in children with dilated cardiomyopathy

پنجمين كنگره بين المللي پيشگيري از بيماريهاي قلب و عروق

7 الي 9 مهر 1395، شيراز - ايران

Presentation Type: Speech
Abstract:

Benefits of intracoronary injection of autologous stem cells on cardiac function and remodelling have been demonstrated in adult patients with acute myocardial infarction and late outcome of this modality was described in several clinical trials. Experience with autologous stem cell therapy in children with severe congenital or acquired pump failure is limited to a small number of case reports.
The largest case series which reported in children was nine children who were treated with intracoronary infusion of autologous bone marrow-derived mononuclear cells.
There are few studies that evaluated stem cell therapy in more complex form of congenital heart disease like single ventricle patients.
On the basis of our data, we propose to perform a pilot study for children with congestive heart failure, to formally assess the efficacy of intracoronary autologous bone marrow cell therapy.

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