Background and Aim: Stem cells (SCs) are capable of renewing themselves through cell division and can be differentiated into tissue or organ - specific cells with special functions under certain physiologic or experimental conditions. These cells are extraordinarily promising in bo th veterinary and human medicine in the view point of therapeutic approaches so, stem cells based cell therapy has appeared as effective therapeutic strategy for treatment of several cancers, infectious and non - infectious diseases.Numerous studies have dem onstrated the remarkable immunosuppressive and antibacterial effects of SCs both in vitro and in vivo, in animal models and in humans.
Methods: Therapeutic administration of MSCs successfully inhibited the bacterial growth and enhances survival by improved clearance of pathogenic bacteria in sepsis and pneumonic conditions.
Results: In recent years, creating resistant stem cells without manipulation is a new way for stem cell therapy. Interestingly, using microbial metabolites for creating resistant stem ce lls is one of new hypothesis for therapy of infectious diseases, wound healing and tissue repairing.
Conclusion: Preconditioned stem cell with microbial metabolites not only increasing survival of SCs in harmful conditions, but also could be improved clear ance of the bacterial infection and finally appeared as effective therapeutic strategy for treatment of several cancers, infectious and non - infectious diseases