The importance oral glucose tolerance test (OGTT) and HbA1c in screening and identification of pre-diabetespersons

The 7 th International & 12 th National Congress on Quality Improvement in Clinical Laboratory

17 till 20 April 2014، Tehran - Iran

Presentation Type: Speech

Introduction and objectives Diabetes is the most common metabolic disease in which blood glucose levels are increased. Diabetes has two types, Type I and Type II. Type one diabetes occurs mostly in young age .Type two diabetes occurs mostly in adults with high per - cent (nearly 90%). Because of the obvious symptoms of type one diabetes and its low percentage in total diabetes, screening tes ts don’t have important role in reducing its individual, social and economic effects. However, type II diabetes and its asymptomatic process, and also it’s slow progress and include the highest percentage of diabetic people, therefore, performing the screening tests for this type is very important .timely diagnosis and prevention and proper education (such as diet, exercise and weight control, etc.) Therefore, in this study we evaluated the importance of oral glucose tolerance test (OGTT) and HbA1C in pre-diabetes screening. Method and materials The study was performed between 2012 and 2013 in Tehran, 367 persons were chosen that they ages were between 30 and 50, and they had fasting blood sugar levels in range of 100 to 110 Mg/dl, and they were overweight and moderately obese (BMI> 25). They received 1gr pure glucose per each 1 kg of body weight and then we gathered the blood samples after one and two hours late r for OGTT test and 1 ml blood was sampled in CBC vial for HbA1C test. Glucose was measured by Colorimetric method, and HbA1C were measured by immune turbido metric method. Results: The results showed that from 367 patients studied who had normal fasting glucose (110-100 mg /dl), 140 persons had high blood glucose (more than 185 mg/dl) after 2 hours and their mean HbA1C was 6.8. Conclusion the results of this study showed although the significant persons had normal fasting blood sugar, But they showed high blood sugar (more than 185 mg/dl) after 2 hours of pure glucose consumption, and they had high HbA1C. Therefore these persons were unknown until they enter in diabetic phase , because of the slow progression of type II diabetes and asymptomatic. Early r ecogni - tion and prevention of diabetes (especially type II) plays an important role in reducing the effects of individual, social and economic aspects. So it is proper to do appropriate screening tests, such as glucose tolerance tests (OGTT),and HbA1C , especially for people over 30 age that they overweight or obese until we have effective role in early diagnosis of pre-diabetic persons and prevent the inci - dence of diabetes and its future damages.