Demographic, Clinical Features and Treatment Outcomes in 700 Patients with Achalasia in Iran

Iranian Congress of Gastroenterology and Hepatology - ICGH 2010

9 till 12 November 2010، Tehran - Iran

Presentation Type: Speech

Introduction: Achalasia is the most recognized motor disorder of the esophagus . Because it is an uncommon disease, most studies have reviewed small numbers of patients .Here, we report demographic and clinical features besides treatment outcomes in 700 achalasic patients who were reffered and managed in our center from 1994-2009. Method: In all patients the diagnosis was established based on clinical, radiological, endoscopic and manometric criteria. A questionnaire was fulfilled for each patient, that included patients age, sex, initial symptom, frequency of different symptoms, presence of positive family history for achalasia, other accompanying diseases and treatment outcomes. Results: In our study men were affected more than women. (54.3% vs.45.7% ). Mean age was about 38 years. Most frequent symptoms were: dysphagia to solids, dysphagia to liquids, active regurgitation, passive regurgitation, and weight loss respectively. Women complained of chest pain more than men (59% versus 47.1%, P value = 0.04). Vast majority of our patients were treated by pneumatic dilation (PD) of the LES and in long-term follow-up 67% of them were in responder group. Females responded better than males to PD. Conclusion: Dysphagia to solids is the most common symptom in patients with achalasia. Chest pain was significantly higher among women. Pneumatic dilation is an effective treatment for achalasia with long-term efficacy in the majority of patients.