Keratinocytes Releasable Factors Function as Anti-Fibrogenic Factors in vitro and in vivo
28 الي 30 بهمن 1389، شيراز - ايران
Presentation Type: Speech
Objective: Although, the promotion of healing in patients with non-healing wounds is desirable, over healing processes such as post-burn hypertrophic scarring (HSc) and keloid are both disfiguring and debilitating. Thus, an essential component of wound healing is its timely cessation. Without it, there can be a build up of excess and often a deleterious fibrotic condition. Termination of wound healing, therefore, requires a fine balance between some key matrix proteins such as collagen deposition and its hydrolysis. As such, like any other dynamic biological process, there must be a set of factors that gradually slow down and/or terminate the dynamic healing process at the late stage of wound healing. However, the nature of these factors is not known.