Hepatitis C Virus

پانزدهمين همايش بين المللي بيماريهاي كودكان

25 الي 1 مهر 1382، تهران - ايران

Presentation Type: Speech
Abstract:

Hepatitis C virus Hepatitis (HCV) has received a lot of media attention and been called a "silent epidemic". Hepatitis C infection is a significant contemporary health problem in the United States and elsewhere. Because it is primarily transmitted via blood, hepatitis C infection presents risks for both nosocomial transmission to patients and occupational spread to health care workers.
The epidemiology of HCV infection in the community in the Western world has changed dramatically over the past two decades, primarily as a result of the indentification of non-A, non-B hepatitis as the major cause of transfusion-associated hepatitis and the development of PCR technology that can accurately detect the hepatitis C virus genome to identify discrete stains of virus. In 1980, the risk of hepatitis C infection associated with transfusion was nearly 20% per unit transfused. By the year 2002 as a result of both self-deferral and aggressive screening of the blood supply, the risk has dropped to less than 0.03% unit transfused.
Current evidence suggests that both CD4+ and CD8+ T lymphocytes play significant roles in host defense against hepatitis C infection. Whether persistent infection produces or is a direct result of abnormal attenuation of Tcell responses is unclear at this time. Though one argument that the virus is responsible for downregulation of CD4+ responses.. Other investigators have incriminated inadequate CD8+ response as a major contributor to viral persistence and chronic infection.

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