نقش ايمني و محفاظتي IDO در پيوند جزاير پانكراس
22 الي 23 آبان 1386، تهران - ايران
نوع ارائه: سخنراني
Immuno-Protective Role of IDO in Islet Transplantation
Presentation Type: Speech
Introduction: Type 1 diabetes mellitus which is considered to be a serious chronic disorder with long-term complications, causes a significant mortality and morbidity in millions of patients worldwide. The only treatment currently available for these patients is repeated daily injections of insulin. Transplantation of the insulin-producing islet cells of the pancreas, which requires only a minor surgical procedure, has been proposed as an ideal approach to replace the efficient insulin regulation that is lost in type 1 diabetic patient. However, the success of this procedure depends on a long term use of the systemic immunosuppressive drugs. Thus, this study was undertaken to seek a novel approach through which a viral vector is used to deliver an immunosuppressive factor, indoleamine 2, 3-dioxygenase (IDO), a tryptophan catabolizing enzyme, gene into syngeneic fibroblasts populated into an engineered a matrix scaffold within which allogenic islets are embedded in. This will generate a tryptophan deficient microenvironment in which infiltrated immune cells, but not allogeneic islets, are unable to proliferate and destroy the engrafted allogeneic islets.