Hepatitis E virus infection in hemodialysis patients: A seroepidemiological survey in Iran

سيزدهمين كنگره بيماريهاي عفوني و گرمسيري ايران

21 الي 25 آذر 1383، تهران - ايران

Presentation Type: Speech

Introduction: The hepatitis E virus (HEV) has a global distribution and is known to have caused large waterborne epidemics of icteric hepatitis. Transmission is generally via the fecal-oral route. Some reports have suggested parent rally transmission of HEV. Anti-¬HEV prevalence data among chronic hemodialysis (HD) patients are few and given conflicting results. Aim of this study was appointment of prevalence of anti-HEV in Tbrizian hemodialysed (HD) patients in 2004.
Methods: This cross-sectional study was conducted in August of 2004. We tested 324 chronic HD patients attending three different units in Tabriz for anti-HEV antibody. A specific solid- phase enzyme-linked immunoassay (Diapro, Italy) was used.
Results: The overall seroprevalence of hepatitis E was 7.4%( 95% CI: 4.6%-10.6%). The prevalence of HBV and HCV infection were 4.6% (95% CI: 2.3%-6.9%) and 20.4% (95% CI: 16%-24.8%) respectively. The seroprevalence of anti-HEV antibody among chronic HD patients was associated significantly with age. In patients younger than 40 years (n=64), the percentage of seropositive individuals was 1.6%, whereas the seroprevalence rate of anti-HEV was 8.8% in 260 subjects 40 years and older (P<0.03). No statistically significant association was observed between HEV seropositivity and blood borne infections.
Conclusion: We observed a high anti-HEV prevalence; there was no association between HEV and blood borne. Infections (HBV, HCV, HIV) in our HD patients; most anti-HEV positive patients we found were probably related to a local infection by HEV. This is the first report concerning seroepidemiology of HEV infection in a large cohort of chronic HD individuals in Iran.