C - Reactive Protein and Coronary Calcium Score Association in Coronary Artery Disease
Background Both high-sensitivity C-reactive protein (hs-CRP) and spiral computed tomography coronary artery calcium score are valid markers of cardiovascular risk. It is unknown whether hs-CRP is a marker of atherosclerotic burden or whether it reflects a process leading to acute coronary events.
Methods We studied the association of high-sensitivity C-reactive protein and coronary calcium score in 143 patients that were candidates for coronary artery bypass graft surgery.
Results In our cross sectional study we found no significant association between high-sensitivity C-reactive protein and coronary calcium score in bivariants (p=0.162) and multivariable (p=0.062) analysis, but in patients who did not use statins, this association was significant and positive in bivariant (p=0.001) and in multivariant analysis this association was negative and significant (p=0.008).
Conclusions High-sensitivity C-reactive protein was not associated with coronary calcium score. The relation between C-reactive protein and clinical events might not be related to atherosclerotic burden. Measures of inflammation, such as C-reactive protein, and indices of atherosclerosis, such as coronary calcium score, are likely to provide distinct information regarding cardiovascular risk.