Expression of p53 and p63 in Oral Lichen Planus and Oral Lichenoid Lesions
Objective: A few samples of oral lichen planus (OLP) and lichenoid reaction (OLL) may be transforming to malignancy. This survey was handled to evaluate of p53 and p63 expression in OLP and OLL according to different aetiopathogenesis, clinical behavior and neoplastic changes of these diseases.
Materials and Methods: Slices gotten from 80 paraffined blocks (40 OLP and 40 OLL) stained by p63 and p53 antibody, using immunohistochemical procedure. The percent of stained cells in basal layer, suprabasal layers and subepithelial inflammation was evaluated.
Results: Expression of p53 in OLP was more than OLL (p<0.0001), but not for p63 expression (p=0.379). Expression of p53 and p63 in two types of OLP (Reticular, Erosive) did not have significant difference (p>0.05). The expression of p53 and p63 in OLP and OLL, in basal layer was more than suprabasal layer and inflammation and in suprabasal layer was more than inflammation. Expression of p53 in basal layer (p=0.012) suprabasal layers (p<0.0001) and inflammation (p=0.003) in OLP was more than OLL, but there was not significant difference between OLP and OLL in expression of p63 in the same areas (p>0.05).
Conclusion: Less expression of p63 in OLP in comparison with p53 is a reason of supportive function for prevention of malignant transformation. Overexpression of wild-type of p53 in OLP is a protective response to increased level of damaged DNA due to chronic inflammation and less expression of p63 in OLP shows coordination activity of these proteins to protection of oral mucosa from harmful effects of inflammation.