Antineutrophil cytoplasmic autoantibodies in uveitis
Anti-neutrophil cytoplasmic autoantibodies were detected in patients with some autoimmune and vascular diseases such as Wegner’s granulomatosis, polyarthritis nodosa and systemic lupus erythematosus. Indirect immunofluorescence technique was employed to detect these autoantibodies. By this method, two general patterns of anti-neutrophil cytoplasmic autoantibodies were seen: A cytoplasmic (C-ANCA) and a perinuclear form (P-ANCA). These antibodies also were observed in uveitis. In this study the presence of anti-neutrophil cytoplasmic autoantibodies in 25 patients with uveitis and its relationship with anatomical location of the disease is evaluated. According to the results anti-neutrophil cytoplasmic autoantibodies was detected in 16% (4 out of 25) of the patients all of them being C-ANCA type. The results also showed that there was not any significant correlation between the presence of anti-neutrophil cytoplasmic autoantibodies and anatomical location of the disease (P=0.65).