Premature Centromere Division and Spontaneous Abortion

International Journal of Medical Toxicology and Forensic Medicine

Volume 3 - Number 2

Article Type: Case report
Abstract: Background: Premature Centromere Division (PCD) was observed in the chromosomes of metaphase spreads in a patient with the history of recurrent abortions.
Case Report: Short term leukocyte cultures were set up with blood sample from the woman with a history of recurrent abortions for the past four consequent years. 25 % of the metaphase spreads screened displayed premature centromere division of the chromosomes in each of the cells.
Conclusion: This abnormal behavior of the centromeres may predispose the individual to cell division errors due to chromosome instability and the consequences of which may be a spontaneous abortion.
قیمت : 20,000 ريال