Multicentric reticulohistiocytosis (MRH) is a rare proliferative histiocytic disease of unknown cause with potentially disabling nature. Primary manifestations are involvement of skin and joints. The articular destruction can lead to permanent joint deformities. Our patient was a 47 year-old woman with bilateral symmetrical polyarthritis and reddish- brown papulonodular cutaneous lesions. The diagnosis of multicentric reticulohistiocytosis was confirmed by histological examination. Both skin and articular manifestations were only partially treated with oral corticosteroids, monthly bolus cyclophosphamide, weekly methotrexate and knee synoviorthesis with nitrogen mustard.