POLYMORPHISMS OF SURVIVIN GENE AND ITS PROTEIN EXPRESSION ARE ASSOCIATED WITH CHRONIC HBV INFECTION IN IRANIAN POPULATION

Hepatitis Monthly

Volume 17 - Number Suppl.1

Article Type: Original Article
Abstract: Purpose: Survivin can affect the progression of infection and is considered as a marker of various malignancies. The aim of the study was to investigate the possible association of gene polymorphisms of survivin (1547A/G, 644C/T, 625 C/G, 241C/T, 31G/C, 141G/C) and chronic hepatitis B infection in Iranian patients.
Methods: The genotypes of survivin SNPs were investigated by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method using 120 chronic HBV infected patients (HBV), 80 spontaneously recovered HBV subjects (SR) and 120 healthy controls (C). Serum level of survivin was determined using ELISA method.
Results: The 1547G, 625C, 241T and 31C alleles were associated with increased susceptibility to chronic hepatitis B infection (P = 0.000, P = 0.000, P = 0.000 and P = 0.000 respectively). Chronic HBV patients with 625CC, 241TT and 31CC genotypes had higher levels of survvin. Moreover, the differences remained significant following applying a Bonferroni correction in the population (PBC<0.05).
Conclusions: Survivin 1547A/G, 625 C/G, 241C/T and 31G/C gene polymorphisms may be associated with chronic HBV susceptibility in Iranian HBV patients.
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