THE RELATIONSHIP BETWEEN LAMC1 GENE POLYMORPHISM AND SUSCEPTIBILITY TO THE CHRONIC HEPATITIS B VIRUS INFECTION IN AN IRANIAN POPULATION

Hepatitis Monthly

Volume 17 - Number Suppl.1

Article Type: Original Article
Abstract: Background: Genetic variants of laminin play functional roles in chronic HBV infection. The objective of this study was to evaluate the association between the LAMC1 gene polymorphisms and HBV susceptibility, in a sample of Iranians.
Methods: The rs20558, rs20563, rs10911193, rs10911251, rs1413390 polymorphisms were analyzed by polymerase chain reaction and PCR-RFLP and ARMS-PCR using 100 chronic HBV infected (HBV) patients, 40 spontaneously recovered HBV (SR) subjects and 100 healthy controls (C). Also, serum levels of laminin were monitored.
Results: The study showed that the existence of rs20558C, rs20563G, rs10911193T alleles significantly increased risk of chronic HBV infection. In addition, CGTAT haplotype had a higher frequency in HBV patients compared to C and SR groups and might be related to the natural history of the infection.Statistical analysis indicated positive correlations between rs20558, rs20563, rs10911193 genotypes and serum levels of the laminin in HBV patients.
Conclusions: According to the statistical analysis, a significant association with susceptibility to chronic HBV infection was observed with rs20558, rs20563 and rs10911193 polymorphisms. In addition, no association of the rs10911251, rs1413390 SNPs with the disease was found.
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