COMPARISON OF INVASIVE AND NON-INVASIVE TESTS FOR ASSESSMENT OF LIVER FIBROSIS IN THE PATIENTS WITH CHRONIC HEPATITIS B AND C

Hepatitis Monthly

Volume 17 - Number Suppl.1

Article Type: Original Article
Abstract: Background: The liver is one of the largest vital organs which could be affected by different infectious diseases such as chronic hepatitis B and C. Nowadays, different methods are used for determining the severity of chronic viral hepatitis and liver fibrosis. Objectives: This study was conducted to compare invasive and non-invasive liver fibrosis tests in the patients with chronic hepatitis B and C.
Methods: In a cross-sectional study, we compared the results of the liver biopsy (used Metavir scoring system) with Fibrosis-4(FIB-4) and aspartate aminotransferase to platelet ratio index (APRI) biomarkers in identifying liver fibrosis in the patients with chronic hepatitis B and C. The data including demographic characteristics, type of hepatitis, serum biomarkers and the results of liver needle biopsy were extracted from the patients’ medical records. FIB-4 and APRI tests were calculated by the specific formula. The data were analyzed with statistical software SPSS version 16.
Results: From 194 patients (77.32% male) with chronic hepatitis, 63 (32.5%) patients had hepatitis B and 131 (67.53%) of them had hepatitis C. The mean of age in the patients with chronic hepatitis B and C was 36.79± 11.98 (range: 16-61) years and 40.89±11.23 (range: 19-82), respectively. There was statistically significant difference between the mean of platelet counts and prothrombin time (PT) at the different levels of Metavir scoring (P<0.05). In the patients with hepatitis B and C, FIB-4 index in cut-off point of 2 had the highest sensitivity and specificity in the diagnosis of mild (F0-F1) and severe fibrosis (F3), respectively. In both types of hepatitis B and C, APRI index in cut-off point of 1.81 had the highest sensitivity and specificity in the diagnosis of mild (F0-F1) and severe fibrosis (F3), respectively.
Conclusions: According the results, in the patients with chronic hepatitis, the severity of liver fibrosis increases with rising of APRI and FIB-4 indices. Therefore, these non-invasive indices can be used instead of invasive diagnostic tests in certain circumstances.
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