The Correlation Between Multiple Sclerosis and Helicobacter pylori Infection
4(3) : 35-36
Article Type: Letter to editor
Abstract: Dear Editor, Multiple sclerosis (MS) is a demyelinating disease of central nervous system and has variety of signs and symptoms and many factors affect its development and progression. MS prevalence varies considerably from high levels in North America and Europe to low rates in Eastern Asia and sub Saharan Africa. In addition, geographical correlations between MS and its prevalence rates have been reported worldwide. The etiology of MS is still unknown but probably a combination of infectious and non-infectious environmental factors trigger the pathogenesis process in each individual. A high Helicobacter pylorifrequency has been reported in various disorders of both CNS and MS. Another study indicates the presence of immunomodulating properties of H. pylori administration in an experimental model of MS, suggesting the possible role of H. pylori infection in the pathophysiology of the MS disease. Risks such as genetic factors, infectious causes, vitamin D insufficiency, exposure to cigarette smoke, and geographic residence have all been well documented in the literature for MS. But, stress, vaccines, traumatic events and allergies have not been identified as risk factors for MS. Nowadays, H. Pylori infection is being evaluated for its relationship with MS are considered. We designed a case-control study to evaluate H. Pyloriinfection status in MS patients.