The effect of Estradiol as luteal phasesupport on pregnancy rate in IVF/ICSIcycles
Introduction: Progesterone is used for lutealphase support and improvement of implantationwhile there is controversy about using estradiol.The aim of this study was to evaluate the effect ofadding estradiol to progesterone as luteal phasesupport in IVF/ICSI cycles.Materials and Methods: In this case controlstudy, infertile women less than 38 years of age,the candidates of ART cycles, were enrolledbetween June 2002 and December 2004 at Royaninstitute. Exclusion criteria consisted of high gradeendometriosis, uterine pathology, serum estradiollevel more than 3000 pg/ml on hCGadministration. Long GnRH agonist protocol wasused for ovarian stimulation. For luteal phasesupport, patients were randomly divided to twogroups: group 1 (Placebo) consisted of patientswho received vaginal supposition of progesteronesupplementation of 400 mg BD on the day ofoocyte retrieval until tenth week of pregnancy plusplacebo. In second group, Estradiol Valrate 4 mgwas initiated orally with progesterone.Results: Sixty seven patients (27 patients inEstradiol group and 40 patients in placebo group)were studied. There were no significant differencesbetween two groups about demographiccharacteristics, Estradiol level on hCG day, 7th and12th day after embryo transfer and progesteroneconcentration on hCG day 7, 10 and 12th afterembryo transfer. While estradiol level on 10th dayafter embryo transfer was statistically significantbetween two groups. Pregnancy rate was alsosimilar between two groups.Conclusion: The role of progesterone as lutealphase support in ART cycles is well determined.There is controversy about adding estradiol forluteal phase support in cycles using GnRH agonist.In present study, adding estradiol as luteal phasesupport, did not affect on pregnancy rate.