The effect of ecstasy administration during pregnancy period on mice fetuses

International Journal of Reproductive BioMedicine

Volume 9 - Number Suppl.2

Article Type: Original Article
Abstract:

Introduction: Addiction is a major public problem, especially in young people. New groups of addict able materials are mental stimulator, such as ecstasy. For example, amphetamines, that over stimulates different parts in body, especially in brain. The aim of this research was to investigate the effect of ecstasy drug on mice embryo at second week and third week during pregnancy period. In addition, fertility potentials of newborn were surveyed. Materials and Methods: A total 20 adult pregnant mice were divided (5 mice in control group and 15 mice in experimental group) randomly. 5 mg/kg of ecstasy was injected as IP in experimental group at second and third week of pregnancy period. In control group, distilled water was injected, instead of ecstasy. After injection, at 18 day of pregnancy, the mice were placed in cage separately up to litter day (day 19-21). The mice offspring were checked for palate, skull, external ear, number of finger, paw, weight, as well as productive potential. Results: From 163 newborn in two groups, no anomalies in skull and external ear were not observed. In control, 46 newborn were born- 30 mice were males and the rest were females. No anomalies were assessed in controls. In experimental group, 117 were born that 78 mice were males. In both groups, there were not significant differences in number of male and female newborn (p=0.08). There was, however, a meaningful difference in newborn with hypoplasia and lack of hypoplasia in paw (p=0.000). There were not meaningful differences in syndactyly in paw (p=0.11). In addition, There were significant differences in fertility potential between control and experimental animals (p=0.000). Conclusion: Utilization of ecstasy during pregnancy is effective on organogenesis and reproductive potential. Therefore, a well-designed clinical study will be useful.