Does maternal age have any effect on the rates of fertilization and embryo development in ICSI cycles?
Introduction: Many factors may affect ICSI outcome, and one of the interesting and important issue for research is to predict this achievement. Besides, it is worthwhile to do this prognosis with invasive tools and one of these invasive tools is maternal age. So, this study was designed to evaluate the role of women’s age on rates of fertilization and embryo development in ICSI cycles. Materials and Methods: In this prospective study, we evaluated the age of 80 patients on the rates of fertilization and embryo development in ICSI cycles. The women aged between 21-42 years old (mean 32.6±5.3). After ICSI, we divided the oocytes into two groups of fertilized and unfertilized, and the maternal age was compared between two groups. Also, female age was compared between groups of good and bad quality embryos and early and late cleaved embryos. Results: There was no significant difference for women age between fertilized and unfertilized groups, 32.3±0.3 and 32.9±0.4, respectively. Also, no significant difference was noticed for maternal age between groups of early and late cleaved embryos (32.2±0.3 and 32.8±0.6, respectively). But, we found significant differences between maternal age in groups of good and bad quality embryos (31.8±0.3 and 33.3±0.5, respectively, p= 0.016). Conclusion: Maternal age may be effective on formation of good embryo development, but has no effect on rates of fertilization and embryo cleavage.