Epidermal Growth Factor Receptor (EGFR) Mutations And Expression In Squamous Cell Carcinoma Of The Esophagus

گوارش، مجله انجمن متخصصين گوارش و كبد ايران

دوره 15 - شماره Supple.1

Article Type: Original Article
Abstract: Introduction:Mutations in Epidermal Growth Factor Receptor (EGFR) are therapeutic targets in lung cancers of never-smokers Method: We have analyzed EGFR mutations (exons 18-21) in 88 Esophageal Squamous Cell Carcinoma (ESCC) patients from high incidence areas in Iran and India Results: Four mutations were detected (5.7%): one in frame deletion (del746-750) and three missense mutations (G719D, L730F, P753L). EGFR overexpression was detected in 22/34 patients tested (65%) whereas no HER2 mutation was found in 54 Kashmiri cases Conclusion: The study suggests that ESCC patients with EGFR mutations may benefit from EGFRtargeted therapies.