The Association Between Chronic Otitis Media And Gastro-Esophageal Reflux Disease

گوارش، مجله انجمن متخصصين گوارش و كبد ايران

دوره 15 - شماره Supple.1

Article Type: Original Article
Abstract: Introduction: This study has been designed to investigate the clinical association between gastro esophageal reflux disease (GERD) and chronic otitis media (COM) in adults and also the role of GERD treatment on the outcome of COM surgery Method: In a clinical trial, patients with COM who were candidates for surgery were evaluated and put in one of two groups; GERD positive (case) and GERD negative (control) patients. Further, the GERD positive patients were randomly assigned to either receive or not receive Omeprazole prior to surgery. The outcome was compared 3 months and 6 months after COM surgery. Results: Fifty-eight patients (26 males) were enrolled. Forty-two (72.4%) had GERD. Three months after surgery recovery in GERD negative patients, was significantly higher (16/16, 100%) than GERD positive patients 28 of 42, 66.7%) (P=0.008). Six months follow up of the GERD negative patients showed significantly higher recovery (16/16, 100 %) than GERD positive patients (29 of 40, 72.5%) (P=0.002). In comparison, 8 of 18 (44.4%) GERD positive patients who did not receive Omeprazole before tympanomastoidectomy recovered after three months whereas, 20 of 24 (83.3%) patients who received Omeprazole recovered during this time (P<0.001). Sixmonths follow up showed recovery of 8 of 18 (44.4%) aseswithoutGERDtreatment and 21 of 22 (95.5%)who received the treatment (Pvalue <0.01). Conclusion: Our data show that presence of GERD significantly affects outcome of tympanomastoidectomy in COM patients. In addition, treating GERD before COM surgery can positively affect the outcomes of tympanomastoidectomy in these patients. Therefore, we suggest that GERD be sought in all patients who are planned to undergo tympanomastoidectomy for COM, and if present be treated prior to surgery. Further larger scale studies are warranted.