Relation between serum leptin levels and helicobacter pylori infection in patients with dyspepsia

گوارش، مجله انجمن متخصصين گوارش و كبد ايران

دوره 15 - شماره Supple.1

Article Type: Original Article
Abstract: Introduction: Relationship between leptin and some gastrointestinal (GI) diseases have been approved during recent years. This study was conducted to assess the relationship between serum leptin level and Helicobacter pylori (HP) infection in patients with dyspepsia. Method: The study population included patients with dyspepsia that fulfilled the ROM II criteria and did not have pathologic findings in endoscopy. After recording demographic data, a biopsy of the stomach was taken for HP assessment and blood sample was drown for leptin measurement. Serum leptin was measured by ELISA method. Results: Totally, 153 patiens were recruited. Mean age of participants was 43.12 years. There was a significant positive relationship between serum leptin level and age (P=0.03). The mean of serum leptin was higher in females than males (0.03). The results of univariate and multivariate analysis showed that serum leptin level was significantly lower in HP positive than HP negative patients (P<0.001). Conclusion: Our findings were in line with some previous ones suggesting that HP infection may reduce serumleptin level.Reducing body fatmass our releasing cytokines due to gastric epithelium injures are possible explanations of this effect. Determination of the exact relationship between these variables in future studies may reveal newer aspects of their roles in physiology and pathogenesis of GI diseases.