Comparison of life style modification, Vitamin E, Metformin and Ursodeoxycholic acid (UDCA) in management of patients with Non Alcoholic fatty liver diseases (NAFLD)

گوارش، مجله انجمن متخصصين گوارش و كبد ايران

دوره 15 - شماره Supple.1

Article Type: Original Article
Abstract: Introduction:Non Alcoholic Fatty liver Diseases (NAFLD) is related to metabolic syndrome. Asymptomatic patients with elevated aminotransferase level and in most cases of cryptogenic cirrhosis, NAFLD is considered as the most common causative factor. Life style modification can be used in management of patients with NAFLD. Present study was designed for comparison of life stylemodifications, vitamin E, Metformin and Ursodeoxycholic acid (UDCA) in management of NAFLD. Method: In present randomized controlled trial 100 patients with NAFLD of gastrointestinal clinic or department of Shahid Sadoughi hospital or private office were included since May 2007. After primary clinical assessment, included patients randomly allocated to four separated group which received life style modification (A),Metformin (B), vitamin E (C) and UDCA (D). Patients were followed six months after begging the trial. Endpoint measurements including liver enzymes and weight of patients were measured every two months during six months follow up period. Results: In the overall Mean of body weight, BMI, AST,ALT andALK of included patients significantly decrease after intervention. Highest weight loss (3.9 Kg) was seen in group (A), highest decrease in mean of AST (27.3 U/L), ALT (42.7 U/L) and ALK (42.7 U/L) were seen in group B, C and D respectively Conclusion: Body weight reduction is as first treatment in patients with NAFLD. Drugs therapy such as Vitamin E, Metformin and UDCA can improve liver enzymes accompanying with weight reduction and dietary regimen. In the other hand reduction of body weight in patients with NAFLD in comparison without expensive drug such as UDAC must be used as first modality choice