Efficacy of probiotics in lactose intolerance patients in Shiraz, Southern Iran

گوارش، مجله انجمن متخصصين گوارش و كبد ايران

دوره 16 - شماره Supple.1

Article Type: Original Article
Abstract: Introduction: The prevalence of lactose intolerance was reported 3-90 percent in different parts of the world. Unabsorbed lactose in large intestine causes digestive problems including bloating, flatulence, nausea, diarrhea and abdominal pain. In the recent years, many studies have been done to find a way to decrease the symptoms such as prescription of probiotics. They are live microorganism that have beneficial effects in reduction of symptoms, some diseases and improve the microbial balance of the host. The aim of this study is to determine the efficacy of probiotics in patients with lactose intolerance in Shiraz, Southern Iran. Method: 54 Referral patients from Motahari Clinic or Gastroenterology Research Center of Shiraz University of Medical Sciences were enrolled. The patients were asked to eat 20 g lactose and after 30 minutes until 3 hours were examined for lactose intolerance using a breath hydrogen test. The clinical and demographic information of all patients were recorded. Probiotic yogurt was administered for patients with lactose intolerance symptoms for 3 weeks and again underwent the breath hydrogen test (Group 1).Acontrol group was considered of patients with lactose intolerance symptoms but received a non-probiotic yogurt identically. Results: In patients of control group, the breath hydrogen test did not show any significant change but in the other group, the change was statistically significant (p=0.011). Conclusion:It seems that probiotics may be effective in treatment of lactose intolerance based on breath hydrogen test. A longer time of follow up may provide the opportunity to follow the symptoms too.