Epidemiology of Inflammatory bowel diseases (IBD) in Iran: A review article and comparative study with Asia

گوارش، مجله انجمن متخصصين گوارش و كبد ايران

دوره 16 - شماره Supple.1

Article Type: Original Article
Abstract: Introduction: The prevalence of inflammatory bowel diseases (IBD) is going to be stabilized in Western Europe and NorthAmerica but has an increasing trend in developing countries in Asia. The epidemiology of IBD in the areas in which, incidence and prevalence are relatively low provides an opportunity for researchers to determine the unknown aspects of them. Method: In this review article, data bases such as Pubmed, Science Direct, Scopus and Medline were searched from 1970 to 2010.The epidemiological aspects which assessed in Iranian articles compared with the same subjects in other Asian countries. The total documented articles on IBD epidemiology were 21 and 52 in Iran and Asia, respectively. Results:According to present review, CTLAgene polymorphism and male/female ratio in ulcerative colitis, the incidence of extra intestinal manifestations, extent of intestinal involvement and family history in both ulcerative colitis and Crohn’s disease in Asia and Iran seems to be different. In contrast, the incidence of primary sclerosing cholangitis in IBD patients, association of NO2/CARD15 mutation and Crohn’s disease as C3435-Talleleandulcerativecolitisarenearlythesame. Conclusion: The rate of IBD has increased significantly in Iran as other Asian countries during the last decade, and an exact, well designed, population based, multi regional epidemiologic study is mandatory due to substantial demographic and characteristic variability in IBD patients in our region.