Comparison of GnRH agonists and antagonists in the outcome of IVF/ICSI in women with polycystic ovary syndrome
Introduction: To compare the outcome of using gonadotropin-releasing hormone (GnRH) antagonists versus agonists in women with polycystic ovary syndrome (PCOS) who underwent controlled ovarian hyper stimulation (COH) for assisted reproductive techniques (ART). Materials and Methods: A total of 120 patients with PCOS were randomly allocated to undergo COH with a GnRH antagonist (Buserelin) (60 patients) and GnRH agonist (Cetrorelix) (60 patients).The primary Outcome measure was pregnancy occurrence. Basal characteristics of the participants, stimulation cycle responses, pregnancy outcomes and incidence of OHSS were considered in both groups. Results: The mean age and the mean of duration infertility of all patients was 28.6±4.4, 5.8±4 respectively. There was no significant difference between the antagonist and agonist arms in the Pregnancy rates, duration of ovarian stimulation, numbers of retrieved oocyte and fertilization rates. Number of gonadotropin ampoules consumed per cycle and incidence of ovarian hyper stimulation syndrome (OHSS) was significantly lower in the antagonist group. Conclusion: It seems because of not significant difference in pregnancy rate between two treatment protocols and positive effect of antagonist in consumed gonadotropin ampoules and OHSS incidence, GnRH Antagonist is more preferable for PCOS women.