Can herbal medicines do lead to ovarian hyper stimulation syndrome? A retrospective cohort study
Introduction: Ovarian hyper stimulation syndrome (OHSS) is an iatrogenic complication that occurs in theluteal phase of an induced hormonal cycle. It is supposed to be a complication of some medications. We aimed to assess the association between herbal medication and OHSS. Materials and Methods: A cohort of 120 married women diagnosed with OHSS participated in this retrospective study from 2011-2013. Among them, 86 cases had history of taking herbal medicine. Vaginal ultrasonography was performed in a Gynecology and Obstetrics Clinic in Jahrom University of Medical Sciences. List of herbs consumed was recorded and data analyzed by SPSS. Results: The participants were aged between 18-51 years (mean: 31). 54% of cases didn't have history of infertility, 36.5% were diagnosed with primary infertility and 9.5% with secondary infertility. 56% of OHSS women having history of taking nigrum (pepper), 30.2% of them used zingiber officinate (ginger), 25.6% used cinnamomum verum (Cinnamon), 19.8% of the cases consumed thymus vulgaris (Thyme), 15.1% of them used carum carvi (cumin) matricaria recutita (Chamomile), 14% of them used thum graveolensdhi (dill) and 14% of them used corocussativus (saffron). Consumption period was from third to eighth day of menstrual cycle for 1-4 months. Dosage of herbal regimes was one tablespoon (3g). The results showed that 100 (93.02%) individuals had mild OHSS, 17 (5.8%) had moderate OHSS and only 3 (1.1%) cases showed severe OHSS. Conclusion: We concluded that the indiscriminate use of herb might lead to OHSS. As the patients tend to consume herbs a lot, we hope to obtain the appropriate dosages of herb and use it as substitute of synthetic drugs with high side effects.