Anti-nociceptive effect of cimetidine in mice: the role of ATP-sensitive potassium channels

Iranian Journal of Pharmaceutical Research

Volume 3 - Number Supple.1

Article Type: Original Article
Recent studies have shown that intracerebroventricular administration of cimetidine (CIM) induces anti-nociceptive and anti–inflammatory effects in rats. However, the underlying mechanism of CIM effect has not been determined yet. This study was planned to determine the anti-nociceptive effect of CIM (50 mg/kg, i.p.) in male mice (25-30 g, n = 80) using tail flick test. Also, the role of ATP-sensitive potassium channels was assessed using glybenclamide (5 mg/kg, i.p.) and minoxidil (2 mg/kg, i.p.) in CIM anti-nociceptive effect. The results showed that CIM significantly induces anti-nociception in mice (P<0.05) and its effect is not dependent on the ATP-sensitive potassium channels. Anti-nociceptive effect of CIM is not related to H2–receptors and K+ channels. However CIM is able to increase brain and plasma morphine levels and can inhibit morphine metabolism.