Evaluation of the effects of dried dill supplements on inflammatory markers, insulin sensitivity and lipid profile abnormalities in patients with type II diabetes

Avicenna Journal of Phytomedicine

Volume 5 - Number Suppl.1

Article Type: Original Article
Abstract: Objectives: Today, medicinal herbs are widely used in complementary medicine, given their fewer side-effects for patient treatment and prevention of diseases including diabetes. The purpose of this study was to investigate the effects of dried dill powder (Anethum graveolens) on inflammatory markers, insulin sensitivity and lipid profile in patients with type II diabetes. Materials and Methods: The present doubleblinded, clinical trial was performed on 60 diabetic patients in Tabriz, Iran in 2013. After meeting the inclusion criteria, the patients were divided into two groups: intervention (daily consumption of 3.3 g of dill powder) and control (the same amount of starch) groups. The study continued for 8 weeks. Interleukin-6, tumor necrosis factor, lipid profile, fasting blood sugar, serum insulin and high-sensitivity C-reactive protein were measured via biochemical methods at the beginning and end of the study. Insulin resistance index was calculated with the use of the following formula: fasting insulin × fasting glucose/405 (IRCT: IRCT201112312017N6). Results: There was a significant decrease in inflammatory factors, fasting insulin, total cholesterol and low-density lipoprotein in the intervention group, even after adjusting the results based on baseline values and confounding variables (p<0.05, p=0.003, p=0.016 and p=0.009, respectively). Surprisingly, dill powder supplements increased the level of fasting blood sugar, although it was not statistically significant. Conclusion: Dill powder could decrease inflammatory factors and improve insulin sensitivity and some lipid parameters. However, further research is required in this area to confirm the findings.