Efficacy of Alum for Treatment of Recurrent Aphthous Stomatitis

Caspian Journal of Internal Medicine

Volume 7 - Number 3

Article Type: Original Article

Background: Recurrent aphthous stomatitis (RAS) is the most common oral mucosal ulcer in humans. The exact etiology of RAS remain poorly understood. Treatment of RAS often includes administration of corticosteroids, analgesics and regulators of the immune system. However, considering the side effects of these medications, even their topical application must be done with caution. Alum is used in traditional medicine for treatment of oral ulcers. This study sought to assess the effect of topical application of alum on aphthous ulcers. Methods: This clinical randomized double-blind placebo controlled study, was conducted on 50 females aged 21 to 27 years. Mucosal adhesive patches were prepared in two forms of basic and 7% alum-containing patches. Subjects in two groups of cases and controls randomly received the mucosal adhesive patches containing alum and the basic patches, respectively at three time for five days points following the formation of aphthous ulcers. Duration of recovery, changes in size of lesion and severity of pain were recorded. Data were entered into SPSS version 16 and analyzed using t-test. Results: Full recovery took averagely 7.52 days in the case and 12.2 days in the control group which was significantly different (P<0.001). Size of wound and severity of pain were significantly lower at one, three and five days post-treatment compared to the baseline values before treatment in the case group(P<0.001) and the difference in this regard between the case and control groups was statistically significant. Conclusions: Alum can significantly decrease the size of aphthous lesions