Assessment of Anethum Graveolens supplementation on the insulin sensitivity and lipid abnormality in type 2 diabetic patients
Background: The use of herbs as an alternative medicine due to the few side effects compare with common used medicine,has been prevailed for treatment and prevention of diseases,recently. Type II diabetes because of changes in life style is a prevalence disorder,7/7% of Iranian population suffer from diabetes and its complications. This study was aimed to investigate the effects of Anethum Graveolens L. supplementation on insulin sensitivity, fasting blood sugar (FBS) and lipid profile markers in type 2 diabetic patients. Methods: This randomized, double-blind, placebo-controlled clinical trial was performed on 60 diabetic patients in Tabriz, Iran between January to March in 2012. Intervention group received 3.3 g/day powder of Anethum for 8 weeks. Serum levels of FBS, Triglyceride (TG), Total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were assessed at the beginning and at the end of the study. Serum insulin level was determined by ELISA method and homeostasis model assessment-insulin resistance (HOMA-IR) calculated as fasting concentrations of blood glucose (mg/dL) × fasting insulin (μU/ml) / 405. Results: Serum insulin level, TC and LDL-C were significantly decreased in the intervention group at the end of study (p=0.003, p=0.016, p=0.009, respectively). Changes in the serum level of HDL-C, TG and HOMA-IR were not significant. Surprisingly, FBS was increased in the intervention group but it was not significantly (p=0.142). Conclusion: Supplementation of diabetic patients with Anethum had beneficial effects on some biochemical markers. Further scientific efforts are suggested to confirm these results.