Comparative analysis of the effects of melatonin and low calorie diet on anthropometric measurements of obese women: A randomized controlled clinical trial

Nutrition and Food Sciences Research

Volume 1 - Number Suppl1

Article Type: Original Article
Abstract:

Background: Obesity has become a global epidemic problem throughout the world. It is estimated that 13.6% of men and 29.5% of women are obese in Iran. The alarming prevalence and an increased risk for various co-morbidities of obesity suggest that current methods in controlling obesity are not efficient enough. It seems more reasonable to consider the other means in addition to the current treatments for obesity such as dietary intervention,behavioral modification and lifestyle changes,to prevent the adverse health consequences of obesity. New data has revealed the beneficial effects of melatonin as a nutritional supplement in weight regulation. The aims of this study were to compare the influence of melatonin supplementation and low calorie diet in obese women. Methods: Forty-four obese women were randomly assigned to melatonin (n = 22) and low calorie diet receiving (n = 22) groups. Subjects were supplemented with a daily dose of 6 mg melatonin or received low calorie diet for 40 days. At the onset and end of the study,body weight,BMI,waist and hip circumference was measured. Independent t test and paired t test were used to compare parameters between and within groups,respectively. An analysis of covariance test was used to adjust the effects of confounding factors. P value 0.05). After intervention,significant reduction was observed in mean bodyweight,BMI,waist and hip circumferences in both study groups (P0.05). Result: There were no significant differences in the baseline measures between the melatonin and low calorie diet receiving groups (P>0.05). After intervention,significant reduction was observed in mean bodyweight,BMI,waist and hip circumferences in both study groups (P<0.05). Although the reduction was greater in melatonin supplemented group than low calorie diet receiving group,but the comparison of changes between groups was not statistically significant (P>0.05). Conclusions: The results showed that,melatonin supplementation may ameliorate obesity and can be recommended as a part of comprehensive strategy involving diet and exercise in managing obesity. However,future studies with higher doses of melatonin and prolonged supplementation period are awaited to confirm our findings.