The Effect of Chlorella Vulgaris supplementation on anthropometric measurements and tumor necrosis factor -α on Non-alcoholic fatty liver disease (NAFLD) patients

Nutrition and Food Sciences Research

Volume 1 - Number Suppl1

Article Type: Original Article
Abstract:

Background: Nonalcoholic fatty liver disease (NAFLD) is a complex disorder that is characterized by fat accumulation in exceeding 5-10% hepatocyte. Inflammation is considered as major contributor in the pathogenesis of NAFLD. Lifestyle modifications are initial step in treatment of NAFLD. Beside Lifestyle modification certain functional foods such as microalgae and bioactive food components have received considerable scientific attention due to their benefits on obesity and inflammation. The aim of this study was to investigate the the Effect of Chlorella Vulgaris supplementation on anthropometric measurements and tumor necrosis factor -α on Non-alcoholic fatty liver disease (NAFLD) patients. Methods: This double-blind randomized placebo-controlled clinical trial was conducted on 70 NAFLD patients confirmed by ultrasonograohy. The subjects were randomly allocated into two groups: 1) “intervention” (n=30) received 400 mg/day vitamin E plus four 300 mg tablets of C.vulgaris before breakfast (1 tablet),lunch (2 tablets) and dinner (1 tablet) and,2) “placebo” (n=30) received 400 mg/day vitamin E and four placebo tablets per day for 8 weeks. Anthropometric measurments (weight,height,waist and hip circumferences) and biochemical parameters including Alanine aminotransferase (ALT),Aspartate aminotransferase (AST),Alkaline phosphatase (ALP) and Tumor necrosis factor-α (TNF-α) as well as liver ultrasonography were assessed at baseline and after 8 weeks. Results: After the intervention weight,waist and hip circumferences showed significant decreases in both groups compared to baseline (P<0.05) and waist to hip ratio decreased only in intervention groups (P<0.05). The mean change in weight was statistically significant between the groups (p=0.01). No significant changes was observed in TNF-α level in both group,while intra- groups changes in TNF-α level was significantly significant (p=0.024). ALT and ALP decreased significantly in both group and AST decreased in intervention group (P<0.001). Among the liver enzymes only ALP reached statistically significant level between two groups (p=0.04). Improvement in liver echogenicity in the intervention and the placebo group were 58% and 42% respectively. Conclusion: Finding of this study suggest that C.vulgaris is decreased anthropometric measurements,TNF-α level and could be considered as an effective supplement in liver function

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