The effects of garlic extract (ajoene) on platelet activity

Avicenna Journal of Phytomedicine

Volume 5 - Number Suppl.1

Article Type: Original Article
Abstract: Objectives: Based on the literature, garlic has numerous health benefits such as anticoagulant properties. Ajoene, which is the main compound of garlic, is an anticoagulant substance, extracted from the alcoholic extracts of this species. Materials and Methods: Twenty diabetic patients were selected in this study. Platelet rich plasma was applied in patients, along with thrombin (first group) and a combination of garlic extract and thrombin (second group). Then, platelet aggregation was measured in both groups, using an aggregometer. Results: The results obtained by the aggregometer showed a reduction in platelet aggregation in the second group. Conclusion: Based on the findings, garlic inhibits fibrinogen receptors. In fact, ajoene interferes with the binding of fibrinogen to its receptor, i.e., GPllb/llla (CD41/61), inhibits the platelet from coagulation and prevents venous thrombosis.