The assessment of rose essence in treatingintractablepharmacoresistant epilepsy in children

Avicenna Journal of Phytomedicine

Volume 5 - Number Suppl.1

Article Type: Original Article
Abstract: Objectives: Epilepsy is a major neurological disorder among children with an approximate incidence of 45 per 100,000 cases per year. Although recently developed antiepileptic drugs (AEDs) could offer better adverse-event profile in comparison to the older-generation AEDs, they may still lead to significant central nervous system (CNS) defects. Rosa damascena is proven to have hypnotic, antispasmodic and relaxant properties which have therapeutic effects on abdominal and chest pains and cardiac strengthening. This study aimed to evaluate the effects of the R. damascena essence on controlling intractable pharmacoresistant epilepsy in children, between 3 to 12 year of age, admittedtothe department of neurology of Ghaem Hospital, Mashhad, Iran. Materials and Methods: In this simple random sampling, medical therapy was conducted in three stages. Initially, 500 cc of R. damascena essence was prepared and a concentration of 10% was obtained with medium-chain triglyceride (MCT). Afterwards, medical and placebo interventions were performed based on patients’ referral prescription using a double-blind approach. The collected data were analyzed using Chi-square, Wilcoxon and Friedman tests and Pearson’s correlation coefficient. Data processing was performed using SPSS and Minitab software packages. Results: In total, we studied 16 patients (male: 56.3% and female: 43.8%),whos emean age was 8.7 years, and the mean age of seizure incidence (first-time seizure) was 16.17 months. The age range of incidence was between 3 days to 48 months. No history of epileptic seizures was observed in 12 cases (75%). In addition, there was a statistically significant difference between the frequency of seizures before and after the treatment with rose oil (p=0.000). The seizures were suppressed in 3 cases (18.7%) and they completely receded in 12 patients (75%). Only in one case (6.25%), no significant differences were observed. Conclusion: Rosa damascena oil could significantly decrease the frequency of epileptic seizures. However, it may not affect the duration of the fits. Moreover, no side effects or complications have been associated with R.damascenaas adjuvant therapy for epileptic pharmacoresistant children.