Relationship between beta-hCG levels in cervicovaginal secretions and labor

International Journal of Gynecology & Obstetrics

Volume 2 - Number

Article Type: ---- Unspecified ----

Objective: To determine whether levels of human beta-chorionic gonadotropin hormone (beta-hCG) in cervicovaginal secretions can predict the labor process. Methods: A total of 150 women admitted in active labor to the urgent delivery unit of a university hospital were enrolled in a prospective study. The beta-hCG level of each woman's cervicovaginal secretions was measured by radioimmunoassay on admission; then, beta-hCG levels were compared between 2 groups of 35 women, one in whom labor progressed normally and another in whom augmentation of labor with oxytocin was required. Results: There were significant differences in beta-hCG levels of cervicovaginal secretions between the spontaneous delivery group and the augmentation of labor group (130.72 +/- 64.51 mU/mL vs. 93.9 +/- 65.29 mU/mL) (P < 0.05). A receiver-operating characteristic (ROC) curve analysis showed that the optimal cut-off value was 82 mU/mL, with a sensitivity of 66% and a specificity of 60%. Conclusion: beta-chorionic gonadotropin hormone levels were significantly higher in the cervicovaginal secretions of women whose labor was progressing normally than in those who required augmentation of tabor. (c) 2005 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.