A randomized palceebo-controlled trial to determine the effect of iron supplementation on pregnancy outcome in pregnant women with haemoglobin >= 13.2 g/dl
Objective To study the effect of iron supplementation on pregnancy outcome in pregnant women with haemoglobin (Hb) >= 13.2 g/dl. Design A randomised, double-blind, placebo -controlled trial. Setting Routine health services. Population Seven hundred and twenty-seven pregnant women with Hb >= 13.2 g/dI in the early stage of the second trimester. Methods Each woman took one tablet of 50 mg of ferrous sulphate daily in the case group (n = 370) or placebo in the control group (n = 357) throughout pregnancy. Main outcome measures Pregnancy outcome. Results While there were no significant differences in demographic and obstetric characteristics between the two groups before any intervention, small- for-gestational-age birth rate and the number of women with hypertension disorder increased significantly in the case group in comparison with the control group (57 [15.7%] versus 36 [10.3%], P = 0.035, 10 [2.7%] versus 3 [8%1, P = 0.05, respectively). Conclusions Our finding proves that routine iron supplementation in nonanaernic women is not rational and may be harmful.