Quantitative Analysis of Pseudoephedrine in Formulation by Potentiometric Membrane Sensor; Computational Investigation
A potentiometric electrode was developed for the rapid determination of pseudoephedrine hydrochloride in pharmaceutical preparations. The electrode incorporates a PVC membrane with a pseudoephedrine-tetraphenyl borate ion-pair complex. The influences of membrane composition, pH of the test solution, and the interfering ions on the electrode performance were investigated. The sensor exhibits a Nernstian response for pseudoephedrine hydrochloride ions over a relatively wide concentration range (1.0x10(-5) to 1.0x10(-1) mol L(-1)) with a slope of 56.2 +/- 0.5 mV per decade at 25 degrees C. It can be used in the pH range of 4.9-6.5. The membrane sensor was successfully applied to determination of pseudoephedrine in its formulations. The agreement mutually verifies the accuracy of experimental method and the validity of computational calculations. Validation of the method shows suitability of the sensors for applies in the quality control analysis of pseudoephedrine hydrochloride in pharmaceutical formulation.