Histological evidence on protective effects of selenium as anti-lead agent in rat salivary glands
Histological changes of rat submandibular glands after chronic treatment with lead acetate (0.05%), selenium (2.5 mg/l) and the combinational of both were investigated in this study. At the end of the treatment, submandibular glands were removed and histological examination by light microscopy was carried out. Lead treatment caused degenerative changes in the cells and induced inflammation and hypertrophy in the glandular tissue. Selenium did not induce any major change as such. Pretreatment by selenium was found to prevent the lead acetate-induced histopathological changes in the glands. It is concluded that selenium can protect rat submandibular glands morphology from lead-induced adverse effects. Properties of selenium as an antioxidant, free radical scavenger and maintenance of cell membrane integrity may be the possible mechanisms involved in this protective process.