Evaluation of acute kidney rejection in 151 recipients

British Journal of Urology

Volume SUPPL. 2 - Number

Article Type: ---- Unspecified ----
Abstract:

Acute Kidney rejection is a serious complication following kidney transplant and a significant proportion of these complications are alluded to deterlorating kidney function in the recipient.Our study was to find out the incidence of this complication,and its relationship to age,gender,type of transplant and the impact of diagnosis and treatment procedures. During a five-year period,a total of 151 kidney transplants were accomplished Serum creatinine, urine volume,sonography,isotope scanning and kidney biopsy were conducted to evaluate the patients who had kidney rejections. In all, we had a total of 43 rejections in 36(23.8%) patients. Rejection encountered in male was 19.8% whereas in female it was 30.9% . The mean age at the time of rejection was 34.9 years in females and 26.1 in males. 88.3% of the rejections followed within 6 months after kidney transplant (mean 53.8 days ). In 36 of these patients,95% had received kidneys from unrelated subjects,whereas 5% had received donations from live relatives. 18 patients (41.8%) were treated with ALG,10 (23.2%) with methyl prednisolone,6(3.9%) with a combination of the two drugs and 6 (3.9%) were not treated. 3 of the patients underwent nephrectomy. In 9 (21%)of the patients,with the aforementioned complication, there had been a total loss of kidney function but mortality secondary to this complication was not seen. Isotope scanning can be termed as the best form of investigation and kidney biopsy as the most sensitive and reliable tool to diagnose acute kidney rejection. The most effective means of treatment include ALG and a combination of ALG and methyl prednisolone does not have a priority over the former.

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